PDF(Pubmed)
Abstract：
Advancing age is associated with several age-related diseases (ARDs), with musculoskeletal conditions impacting millions of elderly people worldwide. With orthopedic conditions contributing towards considerable number of patients, a deeper understanding of bone aging is the need of the hour. One of the underlying factors of bone aging is cellular senescence and its associated senescence associated secretory phenotype (SASP). SASP comprises of pro-inflammatory markers, cytokines and chemokines that arrest cell growth and development. The accumulation of SASP over several years leads to chronic low-grade inflammation with advancing age, also known as inflammaging. The pathways and molecular mechanisms focused on bone senescence and inflammaging are currently limited but are increasingly being explored. Most of the genes, pathways and mechanisms involved in senescence and inflammaging coincide with those associated with cancer and other ARDs like osteoarthritis (OA). Thus, exploring these pathways using techniques like sequencing, identifying these factors and combatting them with the most suitable approach are crucial for healthy aging and the early detection of ARDs. Several approaches can be used to aid regeneration and reduce senescence in the bone. These may be pharmacological, non-pharmacological and lifestyle interventions. With increasing evidence towards the intricate relationship between aging, senescence, inflammation and ARDs, these approaches may also be used as anti-aging strategies for the aging bone marrow (BM).
摘要：
年龄的增长与几种与年龄有关的疾病（ARD）有关，肌肉骨骼疾病影响着全球数百万老年人。由于骨科疾病导致相当多的患者，对骨骼老化有更深入的了解是小时的需要。骨老化的潜在因素之一是细胞衰老及其相关的衰老相关分泌表型(SASP)。SASP包括促炎标志物，抑制细胞生长和发育的细胞因子和趋化因子。SASP的积累超过几年导致慢性低度炎症随着年龄的增长，也被称为发炎。聚焦于骨衰老和炎症的途径和分子机制目前是有限的，但正在越来越多地探索。大部分的基因,涉及衰老和炎症的途径和机制与癌症和其他ARDs如骨关节炎（OA）相关的途径和机制一致。因此，使用测序等技术探索这些途径，识别这些因素并用最合适的方法与之对抗对于健康衰老和早期发现ARD至关重要。可以使用几种方法来帮助再生和减少骨中的衰老。这些可能是药理学的，非药物和生活方式干预。随着越来越多的证据表明衰老之间错综复杂的关系，衰老，炎症和ARD，这些方法也可用作衰老骨髓(BM)的抗衰老策略.
