Abemaciclib 与地昔帕明联用协同增强抗肿瘤作用。
关键词: abemaciclib combined therapy in vivo tricyclic antidepressant
Mesh : Humans Benzimidazoles / pharmacology administration & dosage Aminopyridines / pharmacology administration & dosage Animals Drug Synergism Mice Xenograft Model Antitumor Assays Desipramine / pharmacology Cell Line, Tumor Antineoplastic Combined Chemotherapy Protocols / pharmacology therapeutic use Female Cyclin-Dependent Kinase 4 / antagonists & inhibitors metabolism Cell Proliferation / drug effects Mice, Nude Cyclin-Dependent Kinase 6 / antagonists & inhibitors metabolism MCF-7 Cells HCT116 Cells Antineoplastic Agents / pharmacology therapeutic use administration & dosage Mice, Inbred BALB C
来 源:
DOI:10.3390/ijms25137407
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