PDF(Pubmed)
Abstract：
A large body of evidence indicates that vasopressin (AVP) and steroid hormones are frequently secreted together and closely cooperate in the regulation of blood pressure, metabolism, water-electrolyte balance, and behavior, thereby securing survival and the comfort of life. Vasopressin cooperates with hormones of the hypothalamo-pituitary-adrenal axis (HPA) at several levels through regulation of the release of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and multiple steroid hormones, as well as through interactions with steroids in the target organs. These interactions are facilitated by positive and negative feedback between specific components of the HPA. Altogether, AVP and the HPA cooperate closely as a coordinated functional AVP-HPA system. It has been shown that cooperation between AVP and steroid hormones may be affected by cellular stress combined with hypoxia, and by metabolic, cardiovascular, and respiratory disorders; neurogenic stress; and inflammation. Growing evidence indicates that central and peripheral interactions between AVP and steroid hormones are reprogrammed in cardiovascular and metabolic diseases and that these rearrangements exert either beneficial or harmful effects. The present review highlights specific mechanisms of the interactions between AVP and steroids at cellular and systemic levels and analyses the consequences of the inappropriate cooperation of various components of the AVP-HPA system for the pathogenesis of cardiovascular and metabolic diseases.
摘要：
大量证据表明，血管加压素（AVP）和类固醇激素经常一起分泌，并在调节血压方面密切合作，新陈代谢，水-电解质平衡，和行为，从而确保生存和生活的舒适。血管加压素通过调节促肾上腺皮质激素释放激素（CRH）的释放与下丘脑-垂体-肾上腺轴（HPA）的激素在多个水平上合作，促肾上腺皮质激素（ACTH），和多种类固醇激素，以及通过与目标器官中的类固醇相互作用。这些相互作用由HPA的特定组分之间的正反馈和负反馈促进。总之,AVP和HPA作为一个协调的功能AVP-HPA系统密切合作。研究表明，AVP和类固醇激素之间的合作可能受到细胞应激和缺氧的影响，通过新陈代谢，心血管,和呼吸系统疾病；神经性应激；和炎症。越来越多的证据表明，在心血管和代谢疾病中，AVP和类固醇激素之间的中枢和外周相互作用被重新编程，并且这些重排产生有益或有害的影响。本综述强调了AVP和类固醇之间在细胞和系统水平上相互作用的具体机制，并分析了AVP-HPA系统的各种组件的不适当合作对心血管和代谢疾病的发病机理的后果。
