PDF(Pubmed)
Abstract：
Short chain fatty acids (SCFAs), mainly including acetate, propionate and butyrate, are produced by intestinal bacteria during the fermentation of partially digested and indigestible polysaccharides. SCFAs play an important role in regulating intestinal energy metabolism and maintaining the homeostasis of the intestinal environment and also play an important regulatory role in organs and tissues outside the gut. In recent years, many studies have shown that SCFAs can regulate inflammation and affect host health, and two main signaling mechanisms have also been identified: the activation of G-protein coupled receptors (GPCRs) and inhibition of histone deacetylase (HDAC). In addition, a growing body of evidence highlights the importance of every SCFA in influencing health maintenance and disease development. In this review, we summarized the recent advances concerning the biological properties of SCFAs and their signaling pathways in inflammation and body health. Hopefully, it can provide a systematic theoretical basis for the nutritional prevention and treatment of human diseases.
摘要：
短链脂肪酸（SCFA），主要包括醋酸酯，丙酸和丁酸，在部分消化和不可消化的多糖发酵过程中由肠道细菌产生。SCFA在调节肠道能量代谢和维持肠道环境稳态方面发挥着重要作用,并且在肠道外的器官和组织中也发挥着重要的调节作用。近年来,许多研究表明，SCFA可以调节炎症并影响宿主健康，并且还确定了两个主要的信号传导机制：G蛋白偶联受体（GPCRs）的激活和组蛋白去乙酰化酶（HDAC）的抑制。此外,越来越多的证据强调了每种SCFA在影响健康维护和疾病发展方面的重要性.在这次审查中,我们总结了SCFA的生物学特性及其在炎症和身体健康中的信号通路的最新进展。希望,它可以为人类疾病的营养预防和治疗提供系统的理论依据。
