PDF(Pubmed)
Abstract：
Plants from the Fabaceae family are widely distributed around the world, especially in Europe, Asia and North America. They are a rich source of isoflavones, compounds with estrogen-like activity, which are suspected of having a chemopreventive effect against hormone-dependent cancers. Following the PRISMA guidelines, we conducted a systematic review aimed at assessing the impact of Fabaceae plant extracts on hormone-dependent cancer cells and the content of active compounds in plant raw materials. We analyzed the results of 63 articles from in vitro and in vivo studies describing the effect of plant extracts containing isoflavones on cancer cells, along with their anti-inflammatory and antioxidant potential. In the process, we determined the research limitations and future research directions. The collected results indicate the plant species with potentially high contents of phytoestrogens and anti-inflammatory, antioxidant and cytotoxic properties. They point to the potential use of plants in the diet as a source of compounds offering cancer prevention.
摘要：
豆科植物广泛分布于世界各地,尤其是在欧洲,亚洲和北美。它们是异黄酮的丰富来源，具有雌激素样活性的化合物，怀疑对激素依赖性癌症有化学预防作用。按照PRISMA准则，我们进行了系统综述，旨在评估豆科植物提取物对激素依赖性癌细胞的影响以及植物原料中活性化合物的含量。我们分析了来自体外和体内研究的63篇文章的结果，这些文章描述了含异黄酮的植物提取物对癌细胞的影响，以及它们的抗炎和抗氧化潜力。在这个过程中,我们确定了研究的局限性和未来的研究方向。收集的结果表明植物物种具有潜在的高含量的植物雌激素和抗炎，抗氧化和细胞毒性。他们指出，植物在饮食中的潜在用途是提供癌症预防的化合物的来源。
