PDF(Pubmed)
Abstract：
Previously, we found that a greater dissimilarity in swine leukocyte antigen (SLA) class I and class II alleles between mating partners resulted in increased farrowing rates in a highly inbred population of Microminipigs (MMPs). In this follow-up study, we have analyzed the effects of dissimilarity in SLA alleles between mating partners for seven different reproductive traits, including litter size and the number of stillborn and live or dead weaned piglets. We determined the relationships among reproductive traits within each mating event and the amino acid distances of SLA alleles as markers of diversity between mating partners. Our results indicate that mating partners with greater amino acid pairwise genetic distances in the SLA-1 class I gene or DQB1 class II gene alleles were associated with significantly larger litter sizes and higher numbers of live piglets at birth and weaning. Also, partners with greater pairwise distances in the SLA-2 class I gene alleles exhibited fewer pre-weaning deaths. These findings suggest that the dissimilarity in SLA class I and class II alleles between mating partners may affect not only farrowing rates but also other key reproductive traits such as litter size and improved piglet survival rates. Consequently, SLA alleles could serve as valuable genetic markers for selecting mating partners in breeding programs and for conducting epistatic studies on various reproductive traits in MMPs.
摘要：
以前,我们发现,在猪白细胞抗原(SLA)I类和II类等位基因中,交配伴侣间的差异较大,导致高度近交的微型猪(MMPs)群体产仔率增加.在这项后续研究中，我们分析了七种不同繁殖性状的交配伴侣之间SLA等位基因差异的影响，包括产仔数和死胎、活或死断奶仔猪的数量。我们确定了每个交配事件中生殖性状之间的关系以及SLA等位基因的氨基酸距离作为交配伴侣之间多样性的标记。我们的结果表明，在SLA-1I类基因或DQB1II类基因等位基因中氨基酸成对遗传距离更大的交配伴侣与出生和断奶时产仔数和活猪数量显着相关。此外，SLA-2I类基因等位基因中成对距离较大的伴侣断奶前死亡较少。这些发现表明，交配伴侣之间SLAI类和II类等位基因的差异可能不仅会影响产仔率，还会影响其他关键的繁殖性状，例如产仔数和提高的仔猪存活率。因此,SLA等位基因可以作为有价值的遗传标记，用于在育种计划中选择交配伴侣以及对MMPs中的各种生殖性状进行上位性研究。
