PDF(Pubmed)
Abstract：
Regulatory T cells (Tregs) possess unique immunosuppressive activity among CD4-positive T cells. Tregs are ubiquitously present in mammals and function to calm excessive immune responses, thereby suppressing allergies or autoimmune diseases. On the other hand, due to their immunosuppressive function, Tregs are thought to promote cancer progression. The tumor microenvironment (TME) is a multicellular system composed of many cell types, including tumor cells, infiltrating immune cells, and cancer-associated fibroblasts (CAFs). Within this environment, Tregs are recruited by chemokines and metabolic factors and impede effective anti-tumor responses. However, in some cases, their presence can also improve patient\'s survival rates. Their functional consequences may vary across tumor types, locations, and stages. An in-depth understanding of the precise roles and mechanisms of actions of Treg is crucial for developing effective treatments, emphasizing the need for further investigation and validation. This review aims to provide a comprehensive overview of the complex and multifaceted roles of Tregs within the TME, elucidating cellular communications, signaling pathways, and their impacts on tumor progression and highlighting their potential anti-tumor mechanisms through interactions with functional molecules.
摘要：
调节性T细胞(Tregs)在CD4阳性T细胞中具有独特的免疫抑制活性。Tregs普遍存在于哺乳动物中，并具有镇静过度免疫反应的功能。从而抑制过敏或自身免疫性疾病。另一方面,由于它们的免疫抑制功能，Tregs被认为促进癌症进展。肿瘤微环境(TME)是由许多细胞类型组成的多细胞系统,包括肿瘤细胞,浸润的免疫细胞，和癌症相关成纤维细胞（CAFs）。在这种环境下,Treg被趋化因子和代谢因子募集并阻碍有效的抗肿瘤反应。然而,在某些情况下,它们的存在也可以提高患者的生存率。它们的功能后果可能因肿瘤类型而异，地点,和阶段。深入了解Treg的确切作用和作用机制对于开发有效的治疗方法至关重要。强调需要进一步调查和验证。这篇综述旨在全面概述Tregs在TME中的复杂和多方面的作用，阐明蜂窝通信，信号通路，以及它们对肿瘤进展的影响，并通过与功能分子的相互作用突出了它们潜在的抗肿瘤机制。
