PDF(Pubmed)
Abstract：
The effectiveness of available neuropsychiatric drugs in the era of an increasing number of patients is not sufficient, and the complexity of neuropsychiatric disease entities that are difficult to diagnose and therapeutically is increasing. Also, discoveries about the pathophysiology of neuropsychiatric diseases are promising, including those initiating a new round of innovations in the role of oxidative stress in the etiology of neuropsychiatric diseases. Oxidative stress is highly related to mental disorders, in the treatment of which the most frequently used are first- and second-generation antipsychotics, mood stabilizers, and antidepressants. Literature reports on the effect of neuropsychiatric drugs on oxidative stress are divergent. They are starting with those proving their protective effect and ending with those confirming disturbances in the oxidation-reduction balance. The presented publication reviews the state of knowledge on the role of oxidative stress in the most frequently used therapies for neuropsychiatric diseases using first- and second-generation antipsychotic drugs, i.e., haloperidol, clozapine, risperidone, olanzapine, quetiapine, or aripiprazole, mood stabilizers: lithium, carbamazepine, valproic acid, oxcarbazepine, and antidepressants: citalopram, sertraline, and venlafaxine, along with a brief pharmacological characteristic, preclinical and clinical studies effects.
摘要：
在越来越多的患者时代，可用的神经精神药物的有效性是不够的，难以诊断和治疗的神经精神疾病实体的复杂性正在增加。此外，关于神经精神疾病的病理生理学的发现是有希望的，包括那些在氧化应激在神经精神疾病病因中的作用方面发起新一轮创新的研究。氧化应激与精神障碍高度相关，在治疗中最常用的是第一代和第二代抗精神病药，情绪稳定剂，和抗抑郁药。关于神经精神药物对氧化应激的影响的文献报道存在分歧。他们从证明其保护作用的人开始，以确认氧化还原平衡中的干扰结束。该出版物回顾了使用第一代和第二代抗精神病药物对神经精神疾病最常用疗法中氧化应激作用的知识状况。即，氟哌啶醇,氯氮平,利培酮,奥氮平,喹硫平,或者阿立哌唑,情绪稳定剂：锂，卡马西平,丙戊酸,奥卡西平,抗抑郁药：西酞普兰，舍曲林,和文拉法辛,伴随着一个简短的药理学特征，临床前和临床研究效果。
