PDF(Pubmed)
Abstract：
Prostate adenocarcinoma (PRAD) is the second most common tumor associated with death. The role and mechanisms of the fragile X mental retardation 1 (FMR1) gene in PRAD remain unknown. We conducted an analysis of FMR1 expression in PRAD to determine its prognostic importance and connection to carcinogenic pathways such as PI3K_AKT_mTOR. Survival analyses were utilized to establish a correlation between FMR1 expression and patient outcomes. We used the integration of genomic data with bioinformatic predictions to predict the regulatory factors of the FMR1 gene in PRAD. Our data revealed that individuals with higher levels of FMR1 expression experience worse survival outcomes compared to those with lower expression (hazard ratio [HR] = 5.08, 95% confidence interval [CI] = 1.07 - 24, p = 0.0412). FMR1 expression was significantly higher in patients with advanced pathological tumor stages, particularly in the pT3 and pT4 combined stages and the pN1 nodal stage. Furthermore, patients with high Gleason scores (GSs) (combined GSs 8 and 9) exhibited increased levels of FMR1 expression. Our results further identify a possible regulatory link between FMR1 and key oncogenic pathways, including PI3K_AKT_mTOR, and predict the possible mechanism by which FMR1 is regulated in PRAD. Our data suggest that the FMR1 gene could serve as a biomarker for PRAD progression. However, in-depth investigations, including those with large patient samples and in vitro studies, are needed to validate this finding and understand the mechanisms involved.
摘要：
前列腺腺癌(PRAD)是第二常见的与逝世亡相干的肿瘤。脆性X智力低下1（FMR1）基因在PRAD中的作用和机制尚不清楚。我们对FMR1在PRAD中的表达进行了分析，以确定其预后重要性以及与PI3K_AKT_mTOR等致癌途径的联系。利用生存分析来建立FMR1表达与患者结果之间的相关性。我们使用基因组数据与生物信息学预测的整合来预测PRAD中FMR1基因的调节因子。我们的数据显示，与FMR1表达水平较高的个体相比，FMR1表达水平较低的个体生存结果较差（风险比[HR]=5.08，95％置信区间[CI]=1.07-24，p=0.0412）。FMR1在晚期病理肿瘤分期患者中表达显著增高，特别是在pT3和pT4组合阶段和pN1节点阶段。此外，高Gleason评分(GSs)(GSs8和9组合)的患者FMR1表达水平升高.我们的结果进一步确定了FMR1和关键致癌途径之间可能的调控联系，包括PI3K_AKT_mTOR，并预测FMR1在PRAD中的可能调控机制。我们的数据表明FMR1基因可以作为PRAD进展的生物标志物。然而,深入调查,包括那些有大量患者样本和体外研究的人，需要验证这一发现并理解所涉及的机制。
