PNPLA3 缺陷 iPSC 衍生的肝细胞筛选鉴定了在代谢功能障碍相关的脂肪肝疾病中潜在减少脂肪变性的途径。
关键词: MAFLD NAFLD drug discovery small molecules steatosis stem cells
Mesh : Hepatocytes / metabolism Humans Induced Pluripotent Stem Cells / metabolism Membrane Proteins / metabolism genetics Non-alcoholic Fatty Liver Disease / metabolism genetics pathology etiology Lipase / metabolism genetics Signal Transduction Lipid Metabolism Polymorphism, Single Nucleotide Acyltransferases Phospholipases A2, Calcium-Independent
来 源:
DOI:10.3390/ijms25137277
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