人工智能驱动的分子对接和操纵的分子动力学 , 用于精确选择抗 CD30 嵌合抗原受体的 scFv 。
关键词: CD30 Hodgkin’s lymphoma artificial intelligence (AI) chimeric antigen T cells (CAR-T) coarse grained umbrella sampling (CG-US) molecular docking (MD) steered molecular dynamics (SMD)
Mesh : Receptors, Chimeric Antigen / immunology metabolism genetics Single-Chain Antibodies / immunology chemistry genetics Molecular Dynamics Simulation Humans Molecular Docking Simulation Artificial Intelligence Ki-1 Antigen / immunology metabolism Animals Mice Protein Binding Surface Plasmon Resonance
来 源:
DOI:10.3390/ijms25137231
PDF(Pubmed)