PDF(Pubmed)
Abstract：
In the postantibiotic era, the pathogenicity and resistance of pathogens have increased, leading to an increase in intestinal inflammatory disease. Bacterial infections remain the leading cause of animal mortality. With increasing resistance to antibiotics, there has been a significant decrease in resistance to both inflammation and disease in animals, thus decreasing production efficiency and increasing production costs. These side effects have serious consequences and have detracted from the development of China\'s pig industry. Microcin C7 (McC7) demonstrates potent antibacterial activity against a broad spectrum of pathogens, stable physicochemical properties, and low toxicity, reducing the likelihood of resistance development. Thus, McC7 has received increasing attention as a potential clinical antibacterial and immunomodulatory agent. McC7 has the potential to serve as a new generation of antibiotic substitutes; however, its commercial applications in the livestock and poultry industry have been limited. In this review, we summarize and discuss the biosynthesis, biochemical properties, structural characteristics, mechanism of action, and immune strategies of McC7. We also describe the ability of McC7 to improve intestinal health. Our aim in this study was to provide a theoretical basis for the application of McC7 as a new feed additive or new veterinary drug in the livestock and poultry breeding industry, thus providing a new strategy for alleviating resistance through feed and mitigating drug resistance. Furthermore, this review provides insight into the new functions and anti-infection mechanisms of bacteriocin peptides and proposes crucial ideas for the research, product development, and application of bacteriocin peptides in different fields, such as the food and medical industries.
摘要：
在后抗生素时代，病原体的致病性和抗性增加，导致肠道炎症性疾病的增加。细菌感染仍然是动物死亡的主要原因。随着抗生素耐药性的增加，动物对炎症和疾病的抵抗力显著下降，从而降低了生产效率，增加了生产成本。这些副作用造成了严重的后果,不利于我国养猪业的发展。MicrocinC7（McC7）对广谱病原体具有有效的抗菌活性，稳定的物理化学性质，低毒性,降低抗性发展的可能性。因此，McC7作为一种潜在的临床抗菌和免疫调节剂受到越来越多的关注。McC7具有作为新一代抗生素替代品的潜力；然而，其在畜禽行业的商业应用受到限制。在这次审查中,我们总结并讨论了生物合成，生化特性，结构特征，作用机制,和McC7的免疫策略。我们还描述了McC7改善肠道健康的能力。本研究旨在为McC7作为新型饲料添加剂或新兽药在畜禽养殖业的应用提供理论依据。从而为通过饲料减轻耐药性和减轻耐药性提供了新的策略。此外，本文综述了细菌素肽的新功能和抗感染机制，并提出了重要的研究思路，产品开发,以及细菌素肽在不同领域的应用，例如食品和医疗行业。
