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Abstract：
Chemotherapy is among the main classical approaches to the treatment of oncologic diseases. Its efficiency has been comprehensively proven by clinical examinations; however, the low selectivity of chemotherapeutic agents limits the possibilities of this method, making it necessary to search for new approaches to the therapy of oncologic diseases. Photodynamic therapy is the least invasive method and a very efficient alternative for the treatment of malignant tumors; however, its efficiency depends on the depth of light penetration into the tissue and on the degree of oxygenation of the treatment zone. In this work, a hitherto unknown conjugate of a natural bacteriochlorin derivative and doxorubicin was obtained. In vitro and in vivo studies showed a more pronounced activity of the conjugate against MCF-7 and 4T1 cells and its higher tumorotropicity in animal tumor-bearing animals compared to free anthracycline antibiotic. The suggested conjugate implements the advantages of photodynamic therapy and chemotherapy and has great potential in cancer treatment.
摘要：
化疗是治疗肿瘤疾病的主要经典方法之一。它的效率已被临床检查全面证明；然而，化疗药物的低选择性限制了这种方法的可能性，这使得有必要寻找新的方法来治疗肿瘤疾病。光动力疗法是侵入性最小的方法，是治疗恶性肿瘤的一种非常有效的替代方法；然而，其效率取决于光穿透到组织中的深度和治疗区的氧合程度。在这项工作中,获得了迄今为止未知的天然细菌绿素衍生物和阿霉素的缀合物。体外和体内研究表明，与游离蒽环类抗生素相比，该缀合物对MCF-7和4T1细胞的活性更明显，并且在动物荷瘤动物中具有更高的致瘤性。所提出的缀合物实现了光动力疗法和化学疗法的优点,并且在癌症治疗中具有巨大的潜力。
