PDF(Pubmed)
Abstract：
Small nucleolar RNAs (snoRNAs) are earning increasing attention from research communities due to their critical role in the post-transcriptional modification of various RNAs. These snoRNAs, along with their associated proteins, are crucial in regulating the expression of a vast array of genes in different human diseases. Primarily, snoRNAs facilitate modifications such as 2\'-O-methylation, N-4-acetylation, and pseudouridylation, which impact not only ribosomal RNA (rRNA) and their synthesis but also different RNAs. Functionally, snoRNAs bind with core proteins to form small nucleolar ribonucleoproteins (snoRNPs). These snoRNAs then direct the protein complex to specific sites on target RNA molecules where modifications are necessary for either standard cellular operations or the regulation of pathological mechanisms. At these targeted sites, the proteins coupled with snoRNPs perform the modification processes that are vital for controlling cellular functions. The unique characteristics of snoRNAs and their involvement in various non-metabolic and metabolic diseases highlight their potential as therapeutic targets. Moreover, the precise targeting capability of snoRNAs might be harnessed as a molecular tool to therapeutically address various disease conditions. This review delves into the role of snoRNAs in health and disease and explores the broad potential of these snoRNAs as therapeutic agents in human pathologies.
摘要：
小核仁RNA（snoRNA）由于其在各种RNA的转录后修饰中的关键作用而越来越受到研究界的关注。这些snoRNA，以及它们相关的蛋白质，在调节不同人类疾病中大量基因的表达方面至关重要。首先,snoRNAs促进修饰，如2'-O-甲基化，N-4-乙酰化,和伪吡啶化,这不仅影响核糖体RNA（rRNA）及其合成，而且还影响不同的RNA。功能上,snoRNAs与核心蛋白结合形成小的核仁核糖核蛋白（snoRNPs）。然后，这些snoRNA将蛋白质复合物引导到靶RNA分子上的特定位点，在这些位点上，标准细胞操作或病理机制的调节都需要修饰。在这些目标网站，与snoRNP偶联的蛋白质执行对控制细胞功能至关重要的修饰过程。snoRNAs的独特特征及其在各种非代谢和代谢疾病中的参与突出了它们作为治疗靶标的潜力。此外，snoRNAs的精确靶向能力可能被用作治疗各种疾病的分子工具。这篇综述深入研究了snoRNAs在健康和疾病中的作用，并探讨了这些snoRNAs作为人类病理治疗剂的广泛潜力。
