PDF(Pubmed)
Abstract：
Obesity is a global health challenge that has received increasing attention in contemporary research. The gut microbiota has been implicated in the development of obesity, primarily through its involvement in regulating various host metabolic processes. Recent research suggests that epigenetic modifications may serve as crucial pathways through which the gut microbiota and its metabolites contribute to the pathogenesis of obesity and other metabolic disorders. Hence, understanding the interplay between gut microbiota and epigenetic mechanisms is crucial for elucidating the impact of obesity on the host. This review primarily focuses on the understanding of the relationship between the gut microbiota and its metabolites with epigenetic mechanisms in several obesity-related pathogenic mechanisms, including energy dysregulation, metabolic inflammation, and maternal inheritance. These findings could serve as novel therapeutic targets for probiotics, prebiotics, and fecal microbiota transplantation tools in treating metabolic disruptions. It may also aid in developing therapeutic strategies that modulate the gut microbiota, thereby regulating the metabolic characteristics of obesity.
摘要：
肥胖是一个全球性的健康挑战，在当代研究中受到越来越多的关注。肠道微生物群与肥胖的发展有关，主要通过其参与调节各种宿主代谢过程。最近的研究表明，表观遗传修饰可能是关键途径，肠道微生物群及其代谢物有助于肥胖和其他代谢紊乱的发病机理。因此，了解肠道菌群与表观遗传机制之间的相互作用对于阐明肥胖对宿主的影响至关重要.这篇综述主要集中在理解肠道菌群及其代谢产物与表观遗传机制在肥胖相关致病机制中的关系。包括能量失调,代谢性炎症,和母本继承。这些发现可以作为益生菌的新治疗靶点，益生元,和粪便微生物移植工具治疗代谢紊乱。它还可能有助于开发调节肠道微生物群的治疗策略，从而调节肥胖的代谢特征。
