PDF(Pubmed)
Abstract：
Regulatory T cells (Tregs), a suppressive subpopulation of T cells, are potent mediators of peripheral tolerance, responsible for immune homeostasis. Many autoimmune diseases exhibit disruptions in Treg function or quantity, resulting in an imbalance between protective and pathogenic immune cells. Selective expansion or manipulation of Tregs is a promising therapeutic approach for autoimmune diseases. However, the extensive diversity of Treg subpopulations and the multiple approaches used for Treg identification leads to high complexity, making it difficult to develop a successful treatment capable of modulating Tregs. In this review, we describe the suppressive mechanisms, subpopulations, classification, and identification methodology for Tregs, and their role in the pathogenesis of autoimmune diseases.
摘要：
调节性T细胞(Tregs),抑制性T细胞亚群，是外周耐受性的有效介质，负责免疫稳态。许多自身免疫性疾病表现出Treg功能或数量的破坏，导致保护性和致病性免疫细胞之间的不平衡。Tregs的选择性扩增或操作是自身免疫性疾病的有希望的治疗方法。然而,Treg亚群的广泛多样性和用于Treg鉴定的多种方法导致了高度的复杂性，这使得很难开发能够调节Tregs的成功治疗方法。在这次审查中,我们描述了抑制机制，亚群，分类，以及Tregs的识别方法，以及它们在自身免疫性疾病发病机制中的作用。
