PDF(Pubmed)
Abstract：
Understanding the molecular factors involved in the development of uterine myomas may result in the use of pharmacological drugs instead of aggressive surgical treatment. ANG1, CaSR, and FAK were examined in myoma and peripheral tissue samples taken from women after myoma surgery and in normal uterine muscle tissue samples taken from the control group. Tests were performed using tissue microarray immunohistochemistry. No statistically significant differences in ANG1 expression between the tissue of the myoma, the periphery, and the normal uterine muscle tissue of the control group were recorded. The CaSR value was reduced in the myoma and peripheral tissue and normal in the group of women without myomas. FAK expression was also lower in the myoma and periphery compared to the healthy uterine myometrium. Calcium supplementation could have an effect on stopping the growth of myomas.
摘要：
了解与子宫肌瘤发展有关的分子因素可能会导致使用药理药物而不是积极的手术治疗。ANG1,CaSR,在肌瘤手术后取自女性的肌瘤和外周组织样本以及取自对照组的正常子宫肌肉组织样本中检查了FAK。使用组织微阵列免疫组织化学进行测试。肌瘤组织间ANG1表达无统计学差异，外围,记录对照组正常子宫肌肉组织。在无肌瘤的女性组中，肌瘤和周围组织的CaSR值降低，而正常。与健康子宫肌层相比，FAK在肌瘤和外周中的表达也较低。补充钙可能会阻止肌瘤的生长。
