PDF(Pubmed)
Abstract：
In recent years, there has been a growing realization of intricate interactions between the nervous and immune systems, characterized by shared humoral factors and receptors. This interplay forms the basis of the neuroimmune system, the understanding of which will provide insights into the pathogenesis of neurological diseases, in which the involvement of the immune system has been overlooked. Kynurenine and its derivatives derived from tryptophan have long been implicated in the pathogenesis of various neurological diseases. Recent studies have revealed their close association not only with neurological disorders but also with sepsis-related deaths. This review provides an overview of the biochemistry of kynurenine and its derivatives, followed by a discussion of their role via the modulation of the neuroimmune system in various diseases.
摘要：
近年来,人们越来越认识到神经系统和免疫系统之间复杂的相互作用，以共享的体液因子和受体为特征。这种相互作用形成了神经免疫系统的基础，对其的理解将提供对神经系统疾病发病机理的见解，其中免疫系统的参与被忽视了。犬尿氨酸及其衍生自色氨酸的衍生物长期以来与各种神经系统疾病的发病机理有关。最近的研究表明，它们不仅与神经系统疾病密切相关，而且与败血症相关的死亡也密切相关。本文综述了犬尿氨酸及其衍生物的生物化学，随后讨论了它们通过调节神经免疫系统在各种疾病中的作用。
