PDF(Pubmed)
Abstract：
Pyroptosis, known as one typical mode of programmed cell death, is generally characterized by the cleaved gasdermin family (GSDMs) forming pores in the cell membrane and inducing cell rupture, and the activation of aspartate-specific proteases (caspases) has also been found during this process. Diabetic Kidney Disease (DKD) is caused by the complication of diabetes in the kidney, and the most important kidney\'s function, Glomerular Filtration Rate (GFR), happens to drop to less than 90% of its usual and even lead to kidney failure in severe cases. The persistent inflammatory state induced by high blood glucose implies the key pathology of DKD, and growing evidence shows that pyroptosis serves as a significant contributor to this chronic immune-mediated inflammatory disorder. Currently, the expanded discovery of GSDMs, pyroptosis, and its association with innate immunity has been more attractive, and overwhelming research is needed to sort out the implication of pyroptosis in DKD pathology. In this review, we comb both classical studies and newly founds on pyroptosis, prick off the novel awakening of pyroptosis in DKD, and center on the significance of pyroptosis in DKD treatment, aiming to provide new research targets and treatment strategies on DKD.
摘要：
焦亡,被称为程序性细胞死亡的一种典型模式，通常的特征是裂解的gasdermin家族（GSDMs）在细胞膜上形成孔并诱导细胞破裂，在此过程中还发现了天冬氨酸特异性蛋白酶（caspases）的激活。糖尿病肾病（DKD）是由肾脏糖尿病的并发症引起的，肾脏最重要的功能,肾小球滤过率(GFR),发生下降到低于90％的通常，甚至导致肾功能衰竭在严重的情况下。高血糖引起的持续炎症状态暗示了DKD的关键病理，越来越多的证据表明，焦亡是这种慢性免疫介导的炎症性疾病的重要原因。目前,GSDM的扩展发现，焦亡,它与先天免疫的联系更具吸引力，需要大量的研究来理清焦亡在DKD病理学中的意义。在这次审查中,我们梳理了关于焦亡的经典研究和新发现，刺破了DKD中新型的焦亡觉醒，并集中在DKD治疗中焦亡的重要性，旨在为DKD提供新的研究靶点和治疗策略。
