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Abstract：
Thyroid cancer (TC) is a neoplasm with an increasing incidence worldwide. Its etiology is complex and based on a multi-layered interplay of factors. Among these, disorders of lipid metabolism have emerged as an important area of investigation. Cancer cells are metabolically reprogrammed to promote their rapid growth, proliferation, and survival. This reprogramming is associated with significant changes at the level of lipids, mainly fatty acids (FA), as they play a critical role in maintaining cell structure, facilitating signaling pathways, and providing energy. These lipid-related changes help cancer cells meet the increased demands of continued growth and division while adapting to the tumor microenvironment. In this review, we examine lipid metabolism at different stages, including synthesis, transport, and oxidation, in the context of TC and the effects of obesity and hormones on TC development. Recent scientific efforts have revealed disturbances in lipid homeostasis that are specific to thyroid cancer, opening up potential avenues for early detection and targeted therapeutic interventions. Understanding the intricate metabolic pathways involved in FA metabolism may provide insights into potential interventions to prevent cancer progression and mitigate its effects on surrounding tissues.
摘要：
甲状腺癌（TC）是全球发病率不断上升的肿瘤。其病因是复杂的，基于因素的多层相互作用。其中,脂质代谢紊乱已成为一个重要的研究领域。癌细胞通过代谢重新编程来促进它们的快速生长，扩散,和生存。这种重编程与脂质水平的显着变化有关，主要是脂肪酸（FA），因为它们在维持细胞结构中起着关键作用，促进信号通路，并提供能量。这些与脂质相关的变化有助于癌细胞满足持续生长和分裂的增加的需求，同时适应肿瘤微环境。在这次审查中,我们检查不同阶段的脂质代谢，包括合成，运输,和氧化，在TC的背景下，肥胖和激素对TC发育的影响。最近的科学努力揭示了甲状腺癌特有的脂质稳态紊乱，为早期发现和有针对性的治疗干预开辟了潜在的途径。了解FA代谢中涉及的复杂代谢途径可以提供对预防癌症进展和减轻其对周围组织的影响的潜在干预措施的见解。
