PDF(Pubmed)
Abstract：
The development of vaccines has drastically reduced the mortality and morbidity of several diseases. Despite the great success of vaccines, the immunological processes involved in protective immunity are not fully understood and several issues remain to be elucidated. Recently, the advent of high-throughput technologies has enabled a more in-depth investigation of the immune system as a whole and the characterization of the interactions of numerous components of immunity. In the field of vaccinology, these tools allow for the exploration of the molecular mechanisms by which vaccines can induce protective immune responses. In this review, we aim to describe current data on transcriptional responses to vaccination, focusing on similarities and differences of vaccine-induced transcriptional responses among vaccines mostly in healthy adults, but also in high-risk populations, such as the elderly and children. Moreover, the identification of potential predictive biomarkers of vaccine immunogenicity, the effect of age on transcriptional response and future perspectives for the utilization of transcriptomics in the field of vaccinology will be discussed.
摘要：
疫苗的开发大大降低了几种疾病的死亡率和发病率。尽管疫苗取得了巨大的成功，与保护性免疫有关的免疫过程尚未完全了解，还有几个问题有待阐明。最近,高通量技术的出现使我们能够对整个免疫系统进行更深入的研究，并表征免疫多种成分的相互作用。在疫苗学领域，这些工具可以探索疫苗诱导保护性免疫反应的分子机制。在这次审查中,我们的目的是描述当前的数据转录应答疫苗，重点关注疫苗诱导的转录反应的异同，主要是在健康成年人中，而且在高危人群中，比如老人和孩子。此外，疫苗免疫原性的潜在预测生物标志物的鉴定，将讨论年龄对转录反应的影响以及在疫苗学领域利用转录组学的未来观点。
