PDF(Pubmed)
Abstract：
The field of regenerative medicine is increasingly in need of effective and biocompatible materials for tissue engineering. Human acellular dermal matrix (hADM)-derived collagen matrices stand out as a particularly promising candidate. Their ability to preserve structural integrity, coupled with exceptional biocompatibility, positions them as a viable choice for tissue replacement. However, their clinical application has been largely confined to serving as scaffolds. This study aims to expand the horizon of clinical uses for collagen sheets by exploring the diverse cutting-edge clinical demands. This review illustrates the clinical utilizations of collagen sheets beyond traditional roles, such as covering skin defects or acting solely as scaffolds. In particular, the potential of Epiflex®, a commercially available and immediately clinically usable allogeneic membrane, will be evaluated. Collagen sheets have demonstrated efficacy in bone reconstruction, where they can substitute the induced Masquelet membrane in a single-stage procedure, proving to be clinically effective and safe. The application of these membranes allow the reconstruction of substantial tissue defects, without requiring extensive plastic reconstructive surgery. Additionally, they are found to be apt for addressing osteochondritis dissecans lesions and for ligament reconstruction in the carpus. The compelling clinical examples showcased in this study affirm that the applications of human ADM extend significantly beyond its initial use for skin defect treatments. hADM has proven to be highly successful and well-tolerated in managing various etiologies of bone and soft tissue defects, enhancing patient care outcomes. In particular, the application from the shelf reduces the need for additional surgery or donor site defects.
摘要：
再生医学领域越来越需要用于组织工程的有效和生物相容性材料。人脱细胞真皮基质（hADM）衍生的胶原蛋白基质是特别有前途的候选物。它们保持结构完整性的能力，再加上卓越的生物相容性，将它们定位为组织替代的可行选择。然而,它们的临床应用主要限于用作支架。本研究旨在通过探索不同的尖端临床需求来扩大胶原蛋白片的临床应用范围。这篇综述说明了胶原蛋白片的临床应用，超越了传统的作用，如覆盖皮肤缺损或单独充当支架。特别是,Epiflex®的潜力，一种商业上可获得的和临床上立即可用的同种异体膜，将被评估。胶原蛋白片已证明在骨重建中的功效，他们可以在单阶段程序中替代诱导的Masquelet膜，证明是临床有效和安全的。这些膜的应用可以重建大量的组织缺损，不需要大量的整形手术。此外,他们被发现是适合解决骨软骨炎的病变和韧带重建的。本研究中展示的令人信服的临床实例证实，人类ADM的应用大大超出了其最初用于皮肤缺损治疗的范围。hADM已被证明是非常成功和耐受性良好的管理各种病因的骨和软组织缺损，提高患者护理效果。特别是,从货架上的应用减少了额外的手术或供体部位缺陷的需要。
