PDF(Pubmed)
Abstract：
Endometriosis is a chronic inflammatory disorder characterized by the abnormal growth of endometrial-like tissue outside the uterine cavity, affecting 10-15% of women of reproductive age. Pain is the most common symptom. Treatment options include surgery, which has limited effectiveness and high recurrence rates, and pharmacotherapy. Hormonal therapies, commonly used for symptom management, can have side effects and contraceptive outcomes, contributing to the infertility associated with endometriosis, with pain and lesions often reappearing after treatment cessation. Among its etiological factors, immunological and inflammatory dysregulation plays a significant role, representing an interesting target for developing new therapeutic strategies. This review critically analyzes recent studies to provide an updated synthesis of ongoing research into potential new pharmacotherapies focusing on lesion progression, pain relief, and improving quality of life. Immunotherapy, natural anti-inflammatory and antioxidant compounds and drug repurposing show promise in addressing the limitations of current treatments by targeting immunological factors, potentially offering non-invasive solutions for managing pain and infertility in endometriosis. Promising results have been obtained from in vitro and animal model studies, but clinical trials are still limited. More effort is needed to translate these findings into clinical practice to effectively reduce disease progression, alleviate pain symptoms and preserve the reproductive capacity, improving patients\' overall wellbeing.
摘要：
子宫内膜异位症是一种慢性炎症性疾病，其特征是子宫腔外子宫内膜样组织的异常生长，影响10-15%的育龄妇女。疼痛是最常见的症状。治疗方案包括手术,效果有限，复发率高，和药物治疗。激素疗法,通常用于症状管理，会有副作用和避孕效果，导致与子宫内膜异位症相关的不孕症，疼痛和病变经常在治疗停止后再次出现。在其病因因素中，免疫和炎症失调起着重要的作用，代表开发新的治疗策略的一个有趣的目标。这篇综述批判性地分析了最近的研究，以提供正在进行的研究的最新综合，以关注病变进展的潜在新药物疗法。疼痛缓解,提高生活质量。免疫疗法,天然的抗炎和抗氧化化合物和药物的再利用显示在解决当前治疗的局限性通过针对免疫因素，可能为子宫内膜异位症的疼痛和不孕症提供非侵入性解决方案。从体外和动物模型研究中获得了有希望的结果，但临床试验仍然有限。需要更多的努力将这些发现转化为临床实践，以有效地减少疾病进展，减轻疼痛症状并保持生殖能力，改善患者的整体健康。
