PDF(Pubmed)
Abstract：
There is growing evidence that inflammation impairs erythrocyte structure and function. We assessed the impact of mild systemic inflammation on erythrocyte fragility in three different settings. In order to investigate causation, erythrocyte osmotic fragility was measured in mice challenged with a live attenuated bacterial strain to induce low-grade systemic inflammation; a significant increase in erythrocyte osmotic fragility was observed. To gather evidence that systemic inflammation is associated with erythrocyte fragility in humans, two observational studies were conducted. First, using a retrospective study design, the relationship between reticulocyte-based surrogate markers of haemolysis and high-sensitivity C-reactive protein was investigated in 9292 healthy participants of the UK Biobank project. Secondly, we prospectively assessed the relationship between systemic inflammation (measured by the urinary neopterin/creatinine ratio) and erythrocyte osmotic fragility in a mixed population (n = 54) of healthy volunteers and individuals with long-term medical conditions. Both human studies were in keeping with a relationship between inflammation and erythrocyte fragility. Taken together, we conclude that mild systemic inflammation increases erythrocyte fragility and may contribute to haemolysis. Further research is needed to assess the molecular underpinnings of this pathway and the clinical implications in inflammatory conditions.
摘要：
越来越多的证据表明炎症损害红细胞结构和功能。我们评估了三种不同环境中轻度全身性炎症对红细胞脆性的影响。为了调查因果关系，在用减毒活细菌菌株攻击以诱导低度全身性炎症的小鼠中测量红细胞渗透脆性；观察到红细胞渗透脆性的显着增加。为了收集系统性炎症与人类红细胞脆性相关的证据，进行了两项观察性研究.首先,使用回顾性研究设计，在UKBiobank项目的9292名健康参与者中,研究了基于网织红细胞的溶血替代标志物与高敏C反应蛋白之间的关系.其次,我们前瞻性评估了健康志愿者和有长期疾病的个体的混合人群(n=54)中全身性炎症(用尿新蝶呤/肌酐比值衡量)与红细胞渗透脆性之间的关系.两项人体研究均符合炎症与红细胞脆性之间的关系。一起来看,我们得出的结论是,轻度全身性炎症会增加红细胞脆性,并可能导致溶血.需要进一步的研究来评估该途径的分子基础以及在炎症条件中的临床意义。
