PDF(Pubmed)
Abstract：
Cellular senescence accumulates with age and has been shown to impact numerous physiological and pathological processes, including immune function. The role of cellular senescence in cancer is multifaceted, but the impact on immune checkpoint inhibitor response and toxicity has not been fully evaluated. In this review, we evaluate the impact of cellular senescence in various biological compartments, including the tumor, the tumor microenvironment, and the immune system, on immune checkpoint inhibitor efficacy and toxicity. We provide an overview of the impact of cellular senescence in normal and pathological contexts and examine recent studies that have connected aging and cellular senescence to immune checkpoint inhibitor treatment in both the pre-clinical and clinical contexts. Overall, senescence plays a multi-faceted, context-specific role and has been shown to modulate immune-related adverse event incidence as well as immune checkpoint inhibitor response.
摘要：
细胞衰老随着年龄的增长而积累，并已被证明会影响许多生理和病理过程。包括免疫功能。细胞衰老在癌症中的作用是多方面的，但对免疫检查点抑制剂应答和毒性的影响尚未得到充分评估.在这次审查中,我们评估了细胞衰老在各种生物区室中的影响，包括肿瘤,肿瘤微环境，和免疫系统，免疫检查点抑制剂的疗效和毒性。我们概述了细胞衰老在正常和病理环境中的影响，并检查了在临床前和临床环境中将衰老和细胞衰老与免疫检查点抑制剂治疗联系起来的最新研究。总的来说,衰老起着多方面的作用，具有特定环境的作用，并已被证明可以调节免疫相关不良事件的发生率以及免疫检查点抑制剂的反应。
