Pexidartinib 和免疫检查点抑制剂通过消耗与癌症相关的成纤维细胞分化的 M2 巨噬细胞 , 联合激活小鼠结直肠癌模型中的肿瘤免疫。
关键词: CSF-1R inhibitor cancer-associated fibroblasts colorectal cancer pexidartinib tumor-associated macrophages
Mesh : Animals Colorectal Neoplasms / drug therapy immunology pathology metabolism Cancer-Associated Fibroblasts / metabolism drug effects immunology Mice Immune Checkpoint Inhibitors / pharmacology therapeutic use Cell Differentiation / drug effects Humans Macrophages / immunology metabolism drug effects Tumor Microenvironment / drug effects immunology Aminopyridines / pharmacology therapeutic use Pyrrolidines / pharmacology therapeutic use Cell Line, Tumor Tumor-Associated Macrophages / immunology drug effects metabolism Disease Models, Animal Pyrroles / pharmacology therapeutic use Female CD8-Positive T-Lymphocytes / immunology metabolism drug effects
来 源:
DOI:10.3390/ijms25137001
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