PDF(Pubmed)
Abstract：
Neuroendocrine tumors are uncommon in the gastrointestinal system but can develop in the majority of the body\'s epithelial organs. Our goal was to examine the presence and clinical application of serum dopamine (DA), serotonin (ST), norepinephrine (NE), and epinephrine (EPI), in addition to determining the significance of the Prognostic Nutritional Index (PNI), Glasgow Prognostic Score (GPS), and systemic inflammatory response (SIR) markers as a prognostic factor for patients with colorectal neuroendocrine tumors (CR-NETs), in various tumor-node-metastasis (TNM) stages. We also wanted to identify the possible connection between them. This study included 25 consecutive patients who were diagnosed with CR-NETs and a control group consisting of 60 patients with newly diagnosed colorectal cancer (CRC). We used the Enzyme-Linked Immunosorbent Assay (ELISA) technique. This study revealed that CR-NET patients showed significantly higher serum levels of DA compared to CRC patients. We showed that serum DA was present in the early stages of CR-NETs, with increasing levels as we advanced through the TNM stages. Moreover, we found a close relationship between the levels of DA and the inflammation and nutritional status of the CR-NET patients in this study. CR-NET patients from the PNI < 47.00 subgroup had a higher level of DA than those from the PNI ≥ 47.00 subgroup. Pearson\'s correlation analysis revealed correlations between DA, PNI, and the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR). Both hematological indices were negatively correlated with albumin (ALB). Our investigation\'s findings relating to the PNI, GPS, SIR, and DA indicate that these tools can be markers of nutritional and systemic inflammatory status, are simple to use, and are repeatable. Further research on this topic could provide valuable insights into which biomarkers to incorporate into clinical practice for the management of CR-NET patients.
摘要：
神经内分泌肿瘤在胃肠道系统中并不常见，但可在身体的大部分上皮器官中发展。我们的目标是检查血清多巴胺（DA）的存在和临床应用，血清素(ST),去甲肾上腺素(NE),肾上腺素(EPI),除了确定预后营养指数(PNI)的意义外，格拉斯哥预后评分（GPS），和全身性炎症反应（SIR）标志物作为结直肠神经内分泌肿瘤（CR-NETs）患者的预后因素，在各种肿瘤淋巴结转移（TNM）阶段。我们还想确定它们之间可能的联系。这项研究包括25例被诊断为CR-NETs的连续患者和一个由60例新诊断的结直肠癌（CRC）患者组成的对照组。我们使用酶联免疫吸附测定(ELISA)技术。这项研究表明，与CRC患者相比，CR-NET患者的DA血清水平明显更高。我们发现血清DA存在于CR-NET的早期阶段，随着我们在TNM阶段的进展，水平越来越高。此外，在这项研究中，我们发现DA水平与CR-NET患者的炎症和营养状况密切相关。来自PNI<47.00亚组的CR-NET患者的DA水平高于来自PNI≥47.00亚组的患者。皮尔逊相关分析揭示了DA，PNI,中性粒细胞/淋巴细胞比值(NLR)和血小板/淋巴细胞比值(PLR)。两项血液学指标均与白蛋白(ALB)呈负相关。我们与PNI有关的调查结果，GPS,SIR,和DA表明这些工具可以是营养和全身炎症状态的标志，使用简单，并且是可重复的。对这一主题的进一步研究可以为将哪些生物标志物纳入临床实践以管理CR-NET患者提供有价值的见解。
