PDF(Pubmed)
Abstract：
Pesticides serve as essential tools in agriculture and public health, aiding in pest control and disease management. However, their widespread use has prompted concerns regarding their adverse effects on humans and animals. This review offers a comprehensive examination of the toxicity profile of pesticides, focusing on their detrimental impacts on the nervous, hepatic, cardiac, and pulmonary systems, and their impact on reproductive functions. Additionally, it discusses how pesticides mimic hormones, thereby inducing dysfunction in the endocrine system. Pesticides disrupt the endocrine system, leading to neurological impairments, hepatocellular abnormalities, cardiac dysfunction, and respiratory issues. Furthermore, they also exert adverse effects on reproductive organs, disrupting hormone levels and causing reproductive dysfunction. Mechanistically, pesticides interfere with neurotransmitter function, enzyme activity, and hormone regulation. This review highlights the effects of pesticides on male reproduction, particularly sperm capacitation, the process wherein ejaculated sperm undergo physiological changes within the female reproductive tract, acquiring the ability to fertilize an oocyte. Pesticides have been reported to inhibit the morphological changes crucial for sperm capacitation, resulting in poor sperm capacitation and eventual male infertility. Understanding the toxic effects of pesticides is crucial for mitigating their impact on human and animal health, and in guiding future research endeavors.
摘要：
农药是农业和公共卫生的重要工具，协助病虫害控制和疾病管理。然而,它们的广泛使用引发了人们对它们对人类和动物的不利影响的担忧。这篇综述全面审查了农药的毒性概况，专注于它们对神经的有害影响，肝，心脏,和肺系统，以及它们对生殖功能的影响。此外,它讨论了杀虫剂如何模仿激素，从而诱发内分泌系统功能障碍。农药会扰乱内分泌系统,导致神经损伤，肝细胞异常，心功能不全,和呼吸问题。此外，它们还对生殖器官产生不利影响，扰乱激素水平并导致生殖功能障碍。机械上,杀虫剂干扰神经递质功能，酶活性，和激素调节。这篇综述强调了农药对男性生殖的影响，特别是精子获能，射精精子在女性生殖道内经历生理变化的过程，获得使卵母细胞受精的能力。据报道，杀虫剂可以抑制对精子获能至关重要的形态学变化，导致精子获能不良和最终的男性不育。了解农药的毒性作用对于减轻其对人类和动物健康的影响至关重要。并指导未来的研究工作。
