PDF(Pubmed)
Abstract：
Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, a cornerstone in cancer treatment, aims to destroy cancer cells while minimizing harm to healthy tissues. However, the harmful effects of irradiation on normal cells present a formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines the diverse classes of natural compounds, elucidating their roles as protectants of healthy cells. Furthermore, the review highlights the potential of these compounds as radioprotective agents capable of enhancing the body\'s resilience to radiation therapy. By integrating natural radioprotectors into cancer treatment regimens, clinicians may improve therapeutic outcomes while minimizing the adverse effects on healthy tissues. Ongoing research in this area holds promise for developing complementary strategies to optimize radiotherapy efficacy and enhance patient quality of life.
摘要：
癌症仍然是一个重大的全球健康挑战。每年有数百万人死亡。放射治疗,癌症治疗的基石，目的是破坏癌细胞，同时尽量减少对健康组织的伤害。然而,辐射对正常细胞的有害影响是一个巨大的障碍。为了减轻这些影响，研究人员已经探索使用辐射防护剂和缓解剂，包括来自次生植物代谢产物的天然化合物。这篇综述概述了不同类别的天然化合物，阐明它们作为健康细胞保护剂的作用。此外，该综述强调了这些化合物作为辐射防护剂的潜力，能够增强人体对放射治疗的抵抗力。通过将天然辐射防护剂整合到癌症治疗方案中，临床医生可以改善治疗结果,同时将对健康组织的不利影响降至最低.该领域正在进行的研究有望开发补充策略，以优化放射治疗效果并提高患者的生活质量。
