PDF(Pubmed)
Abstract：
In recent decades, emerging evidence has identified endocrine and neurologic health concerns related to exposure to endocrine-disrupting chemicals (EDCs), including bisphenol A (BPA), certain per- and polyfluoroalkyl compounds (PFASs), and phthalates. This has resulted in consumer pressure to remove these chemicals from the market, especially in food-contact materials and personal care products, driving their replacement with structurally or functionally similar substitutes. However, these \"new-generation\" chemicals may be just as or more harmful than their predecessors and some have not received adequate testing. This review discusses the research on early-life exposures to new-generation bisphenols, PFASs, and phthalates and their links to neurodevelopmental and behavioral alterations in zebrafish, rodents, and humans. As a whole, the evidence suggests that BPA alternatives, especially BPAF, and newer PFASs, such as GenX, can have significant effects on neurodevelopment. The need for further research, especially regarding phthalate replacements and bio-based alternatives, is briefly discussed.
摘要：
近几十年来,新的证据已经确定与暴露于内分泌干扰化学物质（EDC）有关的内分泌和神经系统健康问题，包括双酚A（BPA），某些全氟烷基和多氟烷基化合物(PFAS)，和邻苯二甲酸酯。这导致了消费者从市场上删除这些化学品的压力，特别是在食品接触材料和个人护理产品中，用结构或功能相似的替代品来驱动它们的替代。然而,这些“新一代”化学物质可能与它们的前辈一样或更有害，有些还没有得到足够的测试。这篇综述讨论了生命早期暴露于新一代双酚的研究，PFAS,和邻苯二甲酸盐及其与斑马鱼神经发育和行为改变的联系，啮齿动物,和人类。作为一个整体,证据表明，双酚A的替代品，尤其是BPAF,和较新的PFAS，比如GenX,会对神经发育产生重大影响。需要进一步研究,特别是邻苯二甲酸酯替代品和生物基替代品，简要讨论。
