用于脑和癌症 PET 成像的放射性标记的细胞周期蛋白依赖性激酶 4 和 6 ( CDK4 / 6 ) 抑制剂的开发。
关键词: BBB CDK4/6 CNS PET abemaciclib
Mesh : Cyclin-Dependent Kinase 4 / antagonists & inhibitors metabolism Humans Positron-Emission Tomography / methods Brain Neoplasms / diagnostic imaging drug therapy metabolism enzymology Cyclin-Dependent Kinase 6 / antagonists & inhibitors metabolism Cell Line, Tumor Benzimidazoles / pharmacology chemistry Aminopyridines / chemistry pharmacology Protein Kinase Inhibitors / pharmacology chemistry chemical synthesis Animals Radiopharmaceuticals / chemistry Fluorine Radioisotopes / chemistry Brain / diagnostic imaging metabolism Mice Female
来 源:
DOI:10.3390/ijms25136870
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