STAT5 对于 IL - 2 在宫颈癌细胞系 SiHa 中诱导的代谢开关是必需的。
关键词: IL-2 NAD+/NADH ratio STAT5 cervical cancer lactate metabolic switch
Mesh : Humans STAT5 Transcription Factor / metabolism genetics Uterine Cervical Neoplasms / metabolism pathology genetics Female Cell Proliferation / drug effects Cell Line, Tumor Interleukin-2 / metabolism pharmacology Glycolysis / drug effects Energy Metabolism / drug effects Gene Expression Regulation, Neoplastic / drug effects Phosphorylation / drug effects Glucose Transporter Type 1 / metabolism genetics NAD / metabolism Hypoxia-Inducible Factor 1, alpha Subunit / metabolism genetics Signal Transduction / drug effects Lactic Acid / metabolism
来 源:
DOI:10.3390/ijms25136835
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