PDF(Pubmed)
Abstract：
Resveratrol, acting as a prebiotic, and propionate, functioning as a postbiotic, hold promise for preventing hypertension in chronic kidney disease (CKD). Previously, we employed propionate to enhance the bioavailability of resveratrol through esterification, resulting in the production of a resveratrol propionate ester (RPE) mixture. In this study, we purified 3-O-propanoylresveratrol (RPE2) and 3,4\'-di-O-propanoylresveratrol (RPE4) and investigated their protective effects in a juvenile rat adenine-induced CKD model. To this end, male Sprague Dawley rats aged three weeks (n = 40) were divided into five groups: control; CKD (rats fed adenine); CKRSV (CKD rats treated with 50 mg/L resveratrol); CDRPE2 (CKD rats treated with 25 mg/L RPE2); and CKRPE4 (CKD rats treated with 25 mg/L RPE 4). RPE2 and PRE4 similarly exhibited blood pressure-lowering effects comparable to those of resveratrol, along with increased nitric oxide (NO) availability. Furthermore, RPE2 and RPE4 positively influenced plasma short-chain fatty acid (SCFA) levels and induced distinct alterations in the gut microbial composition of adenine-fed juvenile rats. The supplementation of RPE2 and RPE4, by restoring NO, elevating SCFAs, and modulating the gut microbiota, holds potential for ameliorating CKD-induced hypertension.
摘要：
白藜芦醇,充当益生元，和丙酸，作为后生物，有希望预防慢性肾脏病（CKD）的高血压。以前,我们使用丙酸酯通过酯化来提高白藜芦醇的生物利用度，导致产生白藜芦醇丙酸酯(RPE)混合物。在这项研究中,我们纯化了3-O-丙酰基白藜芦醇（RPE2）和3,4'-二-O-丙酰基白藜芦醇（RPE4），并研究了它们在幼年大鼠腺嘌呤诱导的CKD模型中的保护作用。为此,将三周大的雄性SpragueDawley大鼠（n=40）分为五组：对照组；CKD（饲喂腺嘌呤的大鼠）；CKRSV（用50mg/L白藜芦醇处理的CKD大鼠）；CDRPE2（用25mg/LRPE2处理的CKD大鼠）；和CKRPE4（用25mg/LRPE4处理的CKD大鼠）。RPE2和PRE4同样表现出与白藜芦醇相当的降血压效果，随着一氧化氮（NO）可用性的增加。此外，RPE2和RPE4积极影响血浆短链脂肪酸（SCFA）水平，并诱导腺嘌呤喂养的幼年大鼠的肠道微生物组成发生明显变化。补充RPE2和RPE4，通过恢复NO，提升SCFA，调节肠道微生物群，具有改善CKD诱导的高血压的潜力。
