PDF(Pubmed)
Abstract：
The percentage of obese people is increasing worldwide, causing versatile health problems. Obesity is connected to diseases such as diabetes and cardiovascular diseases, which are preceded by a state called metabolic syndrome. Diets rich in fruits and vegetables have been reported to decrease the risk of metabolic syndrome and type 2 diabetes. Berries with a high polyphenol content, including lingonberry (Vaccinium vitis-idaea L.), have also been of interest to possibly prevent obesity-induced metabolic disturbances. In the present study, we prepared an extract from the by-product of a lingonberry juice production process (press cake/pomace) and investigated its metabolic effects in the high-fat diet-induced model of obesity in mice. The lingonberry skin extract partly prevented weight and epididymal fat gain as well as a rise in fasting glucose level in high-fat diet-fed mice. The extract also attenuated high-fat diet-induced glucose intolerance as measured by an intraperitoneal glucose tolerance test (IPGTT). The extract had no effect on the levels of cholesterol, triglyceride or the adipokines adiponectin, leptin, or resistin. The results extend previous data on the beneficial metabolic effects of lingonberry. Further research is needed to explore the mechanisms behind these effects and to develop further health-promoting lingonberry applications.
摘要：
全世界肥胖者的比例在增加,造成多方面的健康问题。肥胖与糖尿病和心血管疾病等疾病有关，之前是一种叫做代谢综合征的状态。据报道，富含水果和蔬菜的饮食可以降低代谢综合征和2型糖尿病的风险。具有高多酚含量的浆果，包括越橘（Vacciniumvitis-idaeaL.），可能预防肥胖引起的代谢紊乱也引起了人们的兴趣。在本研究中,我们从越橘汁生产过程（压榨饼/果渣）的副产品中制备了提取物，并研究了其在高脂饮食诱导的小鼠肥胖模型中的代谢作用。越橘皮提取物可部分预防高脂饮食小鼠的体重和附睾脂肪增加以及空腹血糖水平升高。通过腹膜内葡萄糖耐量试验（IPGTT）测量，该提取物还减轻了高脂肪饮食诱导的葡萄糖不耐受。提取物对胆固醇水平没有影响，甘油三酯或脂肪因子脂联素，瘦素,或抵抗素。该结果扩展了有关越橘有益代谢作用的先前数据。需要进一步的研究来探索这些作用背后的机制，并开发进一步促进健康的越橘应用。
