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Abstract：
The outcome of total hip arthroplasty (THA) in patients with end-stage arthritis of the hip is associated with preoperative physical status. This study was performed to examine the relationship between the preoperative severity of sarcopenia and clinical outcomes after THA. This retrospective cohort study was performed among 306 consecutive patients (mean age: 63.7 ± 12.9 years, 222 women) undergoing THA at a university hospital. The severity of sarcopenia was determined based on the skeletal muscle mass index (SMI), handgrip strength, and gait speed according to the criteria of the Asian Working Group for Sarcopenia 2019. The severe sarcopenia prevalence rate was 10.6%. Severe sarcopenia was significantly associated with the risk of delayed functional recovery (adjusted odds ratio, 2.82; 95% confidence interval, 1.03-7.72; p = 0.043) compared with the non-sarcopenia group after adjusting for pre-existing risk factors, including preoperative hip function and physical activity. The addition of SMI, handgrip strength, and gait speed to the model for risk of functional recovery delay significantly increased the area under the receiver operating characteristic curve (p = 0.038). Severe sarcopenia was significantly associated with poorer hip function and patient-reported outcomes at 6 months after surgery compared with the non-sarcopenia group. Severe sarcopenia was adversely associated with postoperative clinical outcomes in patients undergoing THA.
摘要：
终末期髋关节关节炎患者的全髋关节置换术（THA）的结果与术前身体状况相关。这项研究旨在检查THA术后肌肉减少症的术前严重程度与临床结局之间的关系。这项回顾性队列研究是在306名连续患者中进行的（平均年龄：63.7±12.9岁，222名妇女）在大学医院接受THA。根据骨骼肌质量指数（SMI）确定肌肉减少症的严重程度，握力,和步态速度根据亚洲工作组2019年的标准。重度肌少症患病率为10.6%。严重的肌肉减少症与延迟功能恢复的风险显着相关（调整后的比值比，2.82；95%置信区间，1.03-7.72；p=0.043）与非肌肉减少症组相比，在调整了预先存在的危险因素后，包括术前髋关节功能和体力活动。添加SMI，握力,功能恢复延迟风险模型的步态速度显着增加了接收器工作特征曲线下的面积（p=0.038）。与非肌肉减少症组相比，严重的肌肉减少症组与术后6个月的髋关节功能和患者报告的预后显着相关。在接受THA的患者中，严重的肌少症与术后临床预后不良相关。
