PDF(Pubmed)
Abstract：
The New Nordic Renal Diet (NNRD) is a whole-food approach, tailored to meet recommended guidelines in patients with moderate chronic kidney disease (stage 3b-4). The NNRD improved various metabolic and physiological endpoints during a 26-week randomized controlled study. Here, we examined the effect of dietary intervention on health-related quality of life (HRQoL). Sixty participants were recruited (NNRD group n = 30, control group n = 30) and 58 completed the study. During the intervention, the NNRD group received food boxes, and recipes once a week. The control group continued their habitual diet. HRQoL was examined at baseline and at the end of the intervention using the validated EuroQol-5D-5L, including a 5-point scale Likert questionnaire at the end of the intervention. Assessed by the EuroQol-5D-5L questionnaire, the NNRD group experienced a reduction in pain/discomfort during the intervention by 26% [-0.44 points (95% CI; -0.73, -0.16)], compared with no change in the control group [0.25 points (95% CI; -0.02, 0.53)] and a between-group difference of -0.70 points (95% CI; -1.03, -0.37, p < 0.001). A larger decrease of body fat mass was associated with a larger decrease in pain/discomfort (p = 0.014). In addition, the NNRD group reported an overall improvement in conducting usual daily activities by 23% [-0.30-point (95% CI; -0.50, -0.11)], while no change was seen in the control group [-0.02 points (95% CI; -0.21, 0.17)], with a between-group difference -0.28 points (95% CI; -0.51, -0.06, p = 0.014). A larger decrease in 24 h urine phosphorus excretion, used as a marker of compliance, was associated with a larger improvement in conducting usual daily activities (p = 0.036). The NNRD group had a clinically relevant improvement in various HRQoL outcomes.
摘要：
新北欧肾脏饮食（NNRD）是一种全食物方法，为满足中度慢性肾脏病患者（3b-4期）的推荐指南而量身定制。在26周的随机对照研究中，NNRD改善了各种代谢和生理终点。这里,我们研究了饮食干预对健康相关生活质量(HRQoL)的影响.招募了60名参与者（NNRD组n=30，对照组n=30），58名参与者完成了研究。在干预期间,NNRD小组收到了食品箱，每周一次的食谱。对照组继续他们的习惯性饮食。使用经过验证的EuroQol-5D-5L在基线和干预结束时检查HRQoL，包括干预结束时的5分量表Likert问卷。由EuroQol-5D-5L问卷评估，NNRD组在干预期间疼痛/不适减少了26%[-0.44分(95%CI;-0.73,-0.16)],对照组无变化[0.25分(95%CI;-0.02,0.53)]，组间差异为-0.70分(95%CI;-1.03,-0.37,p<0.001)。身体脂肪量的较大减少与疼痛/不适的较大减少相关(p=0.014)。此外,NNRD组报告说，在进行日常日常活动方面总体改善了23％[-0.30点（95％CI；-0.50，-0.11）]，而对照组未见变化[-0.02分(95%CI;-0.21,0.17)],组间差异为-0.28分（95%CI；-0.51，-0.06，p=0.014）。24小时尿磷排泄量下降幅度较大，用作合规性的标志，与进行日常活动的较大改善相关（p=0.036）。NNRD组的各种HRQoL结果均有临床相关改善。
