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Abstract：
Background: The sentinel lymph node is the first node that cancer cells reach when migrating from the primary site. However, oncological outcomes after sentinel lymph node biopsy (SNB) have not been reported for cervical cancer. In this study, oncological outcomes were compared between patients receiving SNB and pelvic lymphadenectomy (PLD) for early-stage cervical cancer. Methods: One hundred and four patients with clinical stage 1A2, 1B1, and 2A1 cervical cancer were included in this study. All patients underwent laparoscopic or robot-assisted radical hysterectomy with SNB or PLD. Fifty-two patients with tumors ≤2 cm underwent SNB. Disease-free survival (DFS) and overall survival (OS) were compared between the groups. Results: The median (interquartile range) tumor size was 12 (7-20) mm in the SNB group and 20 (13-25) mm in the PLD group. Lymph node metastasis occurred in one patient in the SNB group and in nine patients in the PLD group. The median follow-up periods were 42 (24-60) and 82 (19-101) months in the SNB group and PLD group, respectively. The 3-year DFS rates were 100% in SNB and 91.5% in PLD. The 3-year OS was 100% in both groups. Conclusions: SNB was sufficient in cervical cancer patients with tumors ≤2 cm, suggesting that PLD might not be necessary for these patients.
摘要：
背景：前哨淋巴结是癌细胞从原发部位迁移时到达的第一个淋巴结。然而,前哨淋巴结活检（SNB）后的肿瘤结局尚未报道宫颈癌。在这项研究中,比较接受SNB和盆腔淋巴结清扫术(PLD)治疗早期宫颈癌的患者的肿瘤结局.方法：本研究包括104例临床分期为1A2，1B1和2A1的宫颈癌患者。所有患者均接受腹腔镜或机器人辅助根治性子宫切除术伴SNB或PLD。52例肿瘤≤2cm患者接受SNB治疗。比较两组患者的无病生存期（DFS）和总生存期（OS）。结果：SNB组的中位（四分位距）肿瘤大小为12（7-20）mm，PLD组为20（13-25）mm。SNB组中有1例患者发生淋巴结转移，PLD组中有9例患者发生淋巴结转移。SNB组和PLD组的中位随访时间分别为42(24-60)和82(19-101)个月,分别。SNB的3年DFS率为100%，PLD为91.5%。两组的3年OS为100%。结论:肿瘤≤2cm的宫颈癌患者SNB足够,提示这些患者可能不需要PLD。
