PDF(Pubmed)
Abstract：
Background/Objectives: This study is based on data collected from a medical health record review to assess whether multidisciplinary intensive rehabilitation treatment in Parkinson\'s disease (PD) patients can improve global cognitive functioning and executive functions. Methods: The data related to PD patients were extrapolated from a clinical database called \"NeuroRehab\". A total of 104 PD patients (51 males; 53 females) performed 6 weeks of multidisciplinary intensive rehabilitation treatment in clinical practice from January 2019 to May 2023. This training program was characterized by three daily sessions of 60 min of activities (muscle relaxation and stretching exercises, moderate physical aerobic exercise, and occupational therapy). The patients were classified and stratified according to disease severity (according to the Hoehn and Yahr scale), postural instability and gait difficulty (PIGD) or tremor-dominant (TD) subtypes, disease duration (DD), and the presence of dyskinesias. The effect of multidisciplinary intensive rehabilitation treatment on cognitive and executive functions was evaluated through the administration of cognitive tests, such as the Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Frontal Assessment Battery (FAB). All the parameters were evaluated at the baseline (T0) and at the end of the rehabilitation program (T1). Results: The multidisciplinary intensive rehabilitation treatment significantly improved cognitive performance. The MMSE, MoCA, and FAB test scores after the rehabilitation program (T1) were significantly higher compared to the scores obtained at the baseline (T0). Moreover, further analyses on subgroups of the patients who scored below the cut-off in the MMSE showed that at least 50% of patients overcame the cut-off score. Interestingly, the same analyses performed for the MoCA and FAB revealed a higher rate of improvement in cognitive functions, with normal scores in both tests after 6 weeks of multidisciplinary intensive rehabilitation treatment. Conclusions: This study revealed the potential effects of a 6-week multidisciplinary rehabilitation program in improving cognitive status in a PD inpatient cohort.
摘要：
背景/目标：本研究基于从医疗健康记录回顾中收集的数据，以评估帕金森病（PD）患者的多学科强化康复治疗是否可以改善整体认知功能和执行功能。方法：从名为“NeuroRehab”的临床数据库中推断与PD患者相关的数据。从2019年1月至2023年5月，共有104例PD患者（男性51例；女性53例）在临床实践中进行了为期6周的多学科强化康复治疗。该培训计划的特点是每天进行3次60分钟的活动（肌肉放松和伸展运动，适度的身体有氧运动，和职业治疗)。根据疾病严重程度（根据Hoehn和Yahr量表）对患者进行分类和分层，姿势不稳定和步态困难（PIGD）或震颤优势（TD）亚型，疾病持续时间（DD），和运动障碍的存在。通过认知测试评估多学科强化康复治疗对认知和执行功能的影响，例如迷你精神状态检查(MMSE)，蒙特利尔认知评估（MoCA）和正面评估电池（FAB）。在基线（T0）和康复计划结束时（T1）评估所有参数。结果:多学科强化康复治疗显著改善认知表现。MMSE,MoCA,康复计划（T1）后的FAB测试得分明显高于基线（T0）。此外，对MMSE评分低于临界值的患者亚组的进一步分析显示,至少有50%的患者克服了临界值.有趣的是,对MoCA和FAB进行的相同分析显示，认知功能的改善率更高，经过6周的多学科强化康复治疗后，两项测试的评分均正常。结论：这项研究揭示了为期6周的多学科康复计划在改善PD住院患者队列认知状态方面的潜在影响。
