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Abstract：
Background: This study investigated the potential link between blood pressure variability (BPV) and the incidence of aortic stenosis (AS) using Korean National Health Insurance Service data from 2002 to 2019. Methods: We collected annual systolic blood pressure variability (SBPV) measurements consisting of three consecutive blood pressure readings each year over three years. The obtained SBPV data was divided into five quantiles, with the highest quintile representing a high fluctuation of blood pressure. Results: Analyzing 9,341,629 individuals with a mean age of 40.7 years, the study found 3981 new AS diagnoses during an average 8.66-year follow-up. Independent predictors for AS included higher blood pressure levels and elevated systolic blood pressure variability (SBPV). The hazard ratios (HR) for different SBPV quintiles compared to the reference (1st quintile) were as follows: 2nd quintile HR 1.09 (p = 0.18), 3rd quintile HR 1.13 (p = 0.04), 4th quintile HR 1.13 (p = 0.04), and 5th quintile HR 1.39 (p < 0.001). Conclusion: Our findings suggest that both hypertension and high fluctuations in SBP during consecutive visits are associated with an increased risk of incident AS. These results emphasize the importance of blood pressure management and stability in the prevention of AS.
摘要：
背景：这项研究使用2002年至2019年的韩国国家健康保险服务数据调查了血压变异性（BPV）与主动脉瓣狭窄（AS）发生率之间的潜在联系。方法：我们收集了每年的收缩压变异性（SBPV）测量值，包括三年中每年连续的三次血压读数。获得的SBPV数据分为五个分位数，最高的五分之一代表血压的高波动。结果：分析了9,341,629名平均年龄为40.7岁的个体，该研究在平均8.66年的随访中发现了3981例新的AS诊断.AS的独立预测因素包括较高的血压水平和升高的收缩压变异性（SBPV）。不同SBPV五分位数与参考（第一五分位数）的风险比（HR）如下：第二五分位数HR1.09（p=0.18），第三五分之一HR1.13(p=0.04)，第四五分之一HR1.13(p=0.04)，和第五五分之一HR1.39(p<0.001)。结论：我们的发现表明，连续就诊期间高血压和SBP的高波动与AS事件的风险增加有关。这些结果强调了血压管理和稳定性在预防AS中的重要性。
