PDF(Pubmed)
Abstract：
Background/Objectives: There are indications that the microbial composition of the maternal mucosal surfaces is associated with adverse events during pregnancy. The aim of this review is to investigate the link between vaginal microbiome alterations and gestational complication risk. Methods: This comprehensive literature review was performed using Medline and Scopus databases. The following search algorithm was used, \"Pregnancy Complications\" [Mesh] AND (Vagin*), and after the literature screening, 44 studies were included in the final review. Results: The studies that were included investigated the association between vaginal microbial composition and preterm birth, miscarriage, preeclampsia, ectopic pregnancy, gestational diabetes mellitus, chorioamnionitis, and preterm premature rupture of membranes. In most of the studies, it was well established that increased microbial diversity is associated with these conditions. Also, the depletion of Lactobacillus species is linked to most of the gestational complications, while the increased relative abundance and especially Lactobacillus crispatus may exert a protective effect in favor of the pregnant woman. Several pathogenic taxa including Gardnerella, Prevotella, Sneathia, Bacterial Vaginosis-Associated Bacteria-2, Atopobium, and Megasphera seem to be correlated to higher maternal morbidity. Conclusions: Vaginal microbiome aberrations seem to have an association with pregnancy-related adverse events, but more high-quality homogenous studies are necessary to reliably verify this link.
摘要：
背景/目的：有迹象表明，母体粘膜表面的微生物组成与怀孕期间的不良事件有关。这篇综述的目的是研究阴道微生物组改变与妊娠并发症风险之间的联系。方法：使用Medline和Scopus数据库进行全面的文献综述。使用了以下搜索算法，\"妊娠并发症\"[网格]和（阴道*），在文献筛选之后，44项研究纳入最终审查。结果：纳入的研究调查了阴道微生物组成与早产之间的关系，流产,先兆子痫,异位妊娠,妊娠期糖尿病,绒毛膜羊膜炎,早产胎膜早破.在大多数研究中，众所周知，微生物多样性的增加与这些条件有关。此外，乳酸菌的消耗与大多数妊娠并发症有关，而相对丰度的增加，尤其是crispatus乳杆菌可能会对孕妇产生保护作用。几种病原类群，包括加德纳菌，普雷沃氏菌,Sneathia,细菌性阴道病相关细菌-2，Atobobium，和Megasphera似乎与更高的产妇发病率有关。结论：阴道微生物组异常似乎与妊娠相关的不良事件有关。但需要更多高质量的同质研究来可靠地验证这一联系。
