PDF(Pubmed)
Abstract：
Background/Objectives: Post-COVID-19 condition can manifest through various symptoms such as dyspnea, cognitive disturbances, and fatigue, with mechanisms related to these symptoms, particularly those related to fatigue, still requiring further clarification. Therefore, our aim was to assess the clinical and physiological variables in patients with post-COVID-19 condition and persistent fatigue. Methods: After one year post-COVID-19 infection, the patients underwent a comprehensive evaluation, including a complete blood count, a metabolic panel, complete spirometry, and assessments of dyspnea, quality of life, anxiety and depression, physical capacity, body composition, muscle strength, comorbidities, and medications. The participants were categorized into two groups: G1-fatigue and G2-non-fatigue. Results: Seventy-seven patients (53% female; 55 ± 11.8 years) were included, 37 in G1 and 40 in G2. As for clinical markers and symptoms of illness, in those with persistent fatigue symptoms, a greater sensation of dyspnea [BDI score: 7.5 (6-9) vs. 12 (9-12), p < 0.001; mMRC score: 1 (1-2) vs. 0 (0-1), p = 0.002], worse quality of life [SGRQ total score: 1404 (1007-1897) vs. 497 (274-985); p < 0.001], higher levels of anxiety [HADS-A score: 8 (5-9) vs. 3 (0.5-4); p < 0.001], and a reduction in peripheral and inspiratory muscle strength [handgrip strength: 34 (28-40) vs. 40 (30-46.5) kgf, p = 0.044; MIP: -81 ± 31 vs. -111 ± 33 mmHg, p < 0.001)] were observed. Conclusions: Those with persistent fatigue exhibited a greater sensation of dyspnea, higher levels of anxiety, reduced peripheral and inspiratory muscle strength, and a greater impairment of quality of life. The severity of fatigue was influenced by the worsening quality of life, heightened anxiety levels, and decreased peripheral muscle strength. Additionally, the worse quality of life was associated with a higher sensation of dyspnea, lower muscle strength, and reduced physical capacity.
摘要：
背景/目标：COVID-19后病症可通过各种症状表现，如呼吸困难，认知障碍，和疲劳，与这些症状相关的机制，特别是那些与疲劳有关的，仍然需要进一步澄清。因此,我们的目的是评估COVID-19后病情和持续性疲劳患者的临床和生理变量.方法：COVID-19感染后一年，对患者进行了全面评估，包括全血细胞计数,代谢小组，完整的肺活量测定，和呼吸困难的评估，生活质量,焦虑和抑郁,物理能力，身体成分,肌肉力量,合并症,和药物。参与者分为两组：G1-疲劳和G2-非疲劳。结果：包括77例患者（53％为女性；55±11.8岁），37在G1和40在G2。至于临床标志物和疾病症状，那些有持续性疲劳症状的人,更大的呼吸困难感觉[BDI评分：7.5（6-9）与12(9-12)p<0.001；mMRC评分：1（1-2）与0(0-1),p=0.002],生活质量较差[SGRQ总分：1404（1007-1897）vs.497（274-985）；p<0.001]，更高水平的焦虑[HADS-A评分：8（5-9）与3（0.5-4）；p<0.001]，外周和吸气肌肉力量[手握力量：34（28-40）与40(30-46.5)kgf,p=0.044；MIP：-81±31vs.-111±33mmHg,观察到p<0.001)]。结论：持续性疲劳者表现出更大的呼吸困难感，更高水平的焦虑，减少外周和吸气肌肉力量，以及对生活质量的更大损害。疲劳的严重程度受到生活质量恶化的影响，焦虑水平升高，外周肌肉力量下降。此外,较差的生活质量与较高的呼吸困难感有关，肌肉力量降低,身体能力下降。
