PDF(Pubmed)
Abstract：
Exposure to ionizing radiation (IR) is inevitable in various X-ray imaging examinations, with computed tomography (CT) being a major contributor to increased human radiation exposure. Ionizing radiation may cause structural damage to macromolecules, particularly DNA, mostly through an indirect pathway in diagnostic imaging. The indirect pathway primarily involves the generation of reactive oxygen species (ROS) due to water radiolysis induced by IR, leading to DNA damage, including double-strand breaks (DSB), which are highly cytotoxic. Antioxidants, substances that prevent oxidative damage, are proposed as potential radioprotective agents. This Study Protocol article presents the rationale for selecting vitamin C as a preventive measure against CT-associated IR-induced DNA damage, to be investigated in a randomized placebo-controlled trial, with a full in vivo design, using an oral easy-to-use schedule administration in the outpatient setting, for the single CT examination with the highest total global IR dose burden (contrast-enhanced abdomen and pelvis CT). The study also aims to explore the mediating role of oxidative stress, and it has been written in adherence to the Standard Protocol Items recommendations.
摘要：
在各种X射线成像检查中，暴露于电离辐射（IR）是不可避免的，计算机断层扫描（CT）是增加人体辐射暴露的主要原因。电离辐射可能会对大分子造成结构损伤,特别是DNA,主要是通过诊断成像的间接途径。间接途径主要涉及由于IR诱导的水辐射分解而产生的活性氧（ROS），导致DNA损伤,包括双链断裂(DSB)，具有高度细胞毒性。抗氧化剂,防止氧化损伤的物质，被提议作为潜在的辐射防护剂。本研究方案文章介绍了选择维生素C作为预防CT相关IR引起的DNA损伤的预防措施的基本原理。在一项随机安慰剂对照试验中进行调查，具有完整的体内设计，在门诊环境中使用口服易于使用的时间表给药，对于具有最高总IR剂量负担的单次CT检查（对比增强腹部和骨盆CT）。本研究还旨在探讨氧化应激的中介作用，并遵守标准议定书项目建议。
