PDF(Pubmed)
Abstract：
Background: Recent studies increasingly highlight the efficacy of tranexamic acid administration in total hip arthroplasty (THA) and total knee arthroplasty (TKA). However, the optimal dosage of tranexamic acid is still controversial. Methods: The current study analyzes the efficiency of tranexamic acid dosage and the number of administrations in THA and TKA. The objective of this study is to compare the incidence of deep vein thrombosis (DVT) based on the number of dosages. We divided the patients into two groups; one group received a single dosage, and the other group received two dosages. Doppler ultrasound examinations were conducted on the lower limbs of all patients at both six and thirty days postoperatively. The second objective is to compare the decrease in hemoglobin (Hb) in the two groups. Results: The results show that there is no difference in DVT incidence between the patients with different TXA numbers of dosages. There is no statistically significant decrease in Hb between the two groups at day one and day five postoperatively. Day one shows a statistically higher average in the two-dose group, approximately 0.06 g/dL, and day five shows a slightly elevated average in the single-dose group, approximately 0.06 g/dL. Blood transfusion requirements show no significant differences in the groups; one patient in the single-dose tranexamic acid group needed transfusion at day five postoperatively, while two patients in each group required immediate postoperative transfusion. Conclusion: There was no increase in the incidence of deep vein thrombosis among patients receiving two dosages of tranexamic acid.
摘要：
背景：最近的研究越来越强调氨甲环酸在全髋关节置换术（THA）和全膝关节置换术（TKA）中的疗效。然而,氨甲环酸的最佳用量仍存在争议。方法：本研究分析了THA和TKA中氨甲环酸剂量和给药次数的效率。这项研究的目的是根据剂量数比较深静脉血栓形成（DVT）的发生率。我们将患者分为两组；一组接受单一剂量，另一组接受两种剂量。术后6天和30天对所有患者的下肢进行多普勒超声检查。第二个目标是比较两组中血红蛋白（Hb）的降低。结果：结果表明，不同TXA剂量的患者DVT发生率无差异。术后第1天和第5天两组间Hb无统计学显著下降。第一天在两剂量组中显示出统计学上较高的平均值，大约0.06g/dL，第5天显示单剂量组的平均值略有升高，约0.06g/dL。输血需求在各组中没有显着差异；单剂量氨甲环酸组的一名患者在术后第五天需要输血，而每组有两名患者需要术后立即输血。结论：接受两种剂量氨甲环酸的患者深静脉血栓的发生率没有增加。
