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Abstract：
Background/Objectives: Pyoderma gangrenosum (PG) is a rare, autoimmune skin condition characterized by painful, rapidly progressing ulcers, often associated with autoimmune dysregulation. Managing PG following breast surgery presents unique challenges due to its pathergy phenomenon, which complicates surgical interventions. This article outlines the case of PG in a 48-year-old female post-breast surgery and reviews management strategies through a systematic analysis of the literature. Methods: A systematic literature review from 2018 to 2023 identified 24 relevant articles on PG management post-breast surgery. The studies were analyzed to compare the efficacy and complications of conservative versus combined (conservative and surgical) treatment strategies. Results: Results indicate that while conservative management, primarily with corticosteroids, remains preferred, combined strategies, including systemic therapies, vacuum-assisted closure, and surgery, offer significant benefits in select cases. Conclusions: Our findings suggest that a personalized, multifaceted treatment plan is crucial for managing PG effectively, emphasizing the need for early detection, meticulous planning, and comprehensive care to optimize patient outcomes.
摘要：
背景/目的：坏疽性脓皮病（PG）是一种罕见的，以疼痛为特征的自身免疫性皮肤病，快速进展的溃疡，通常与自身免疫失调有关。由于乳房手术的pathergy现象，管理PG提出了独特的挑战，这使得手术干预复杂化。本文概述了一名48岁女性乳房手术后PG的病例，并通过对文献的系统分析回顾了管理策略。方法：2018年至2023年的系统文献回顾，确定了24篇关于乳腺术后PG管理的相关文章。对这些研究进行了分析，以比较保守与联合（保守和手术）治疗策略的疗效和并发症。结果：结果表明，虽然保守管理，主要是皮质类固醇，仍然是首选，联合战略，包括全身疗法,真空辅助闭合,和手术，在选定的情况下提供显著的好处。结论：我们的研究结果表明，个性化，多方面的治疗计划对于有效管理PG至关重要，强调早期检测的必要性，精心策划,和全面的护理，以优化患者的预后。
