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Abstract：
Background: Knee osteoarthritis is a degenerative and inflammatory disease causing pain and worsening patients\' quality of life. Various conservative treatment options exist, but a gap between scientific evidence and clinical practice is still present. The aim of this prospective multicenter observational study is to describe the real outpatient territorial management of patients with knee osteoarthritis and to analyze the correlation between the anthropometric and clinical characteristics of the population of patients suffering from symptomatic knee osteoarthritis who were screened in the national survey. Methods: The educational national project was divided into three modules: the first and the last through webinars; and the second held in daily practice. The participants had to register structured observations, which were then stored in a national database and analyzed in order to identify correlations. The subgroups were stratified by body composition, radiological severity of knee osteoarthritis, pain, and functional ability. Results: The project has been joined by 155 physicians, and 2.656 observations about real-world outpatients being treated for knee osteoarthritis in Italy were collected. Data relating to real-world pharmacological and rehabilitation therapies in correlation with body composition, the radiological severity of knee osteoarthritis, pain, and functional ability were reported. Conclusions: Currently, there are no standardized protocols using effective combinations of therapeutic exercises, physical agents, and medications to control the progression of knee osteoarthritis. This real-word national survey proved to be useful for describing the current state of the art of therapeutic management of knee osteoarthritis and for emphasizing the need to fill the gap between scientific evidence and clinical practice.
摘要：
背景：膝关节骨性关节炎是一种退行性和炎症性疾病，引起疼痛并恶化患者的生活质量。存在各种保守治疗选择，但是科学证据和临床实践之间的差距仍然存在。这项前瞻性多中心观察性研究的目的是描述膝骨关节炎患者的真实门诊地域管理，并分析在全国调查中筛查的症状性膝骨关节炎患者人群的人体测量和临床特征之间的相关性。方法：教育国家项目分为三个模块：第一个和最后一个通过网络研讨会；第二个在日常实践中举行。参与者必须登记结构化的观察，然后将其存储在国家数据库中并进行分析以确定相关性。亚组按身体成分分层，膝骨关节炎的放射学严重程度，疼痛,和功能能力。结果：该项目已由155名医生加入，收集了2.656个关于在意大利接受膝关节骨关节炎治疗的真实世界门诊患者的观察结果。与身体成分相关的真实世界药理学和康复治疗数据，膝骨关节炎的放射学严重程度，疼痛,和功能能力报告。结论：目前，没有使用有效组合治疗练习的标准化方案，物理代理，以及控制膝骨关节炎进展的药物.这项真实的国家调查被证明有助于描述膝关节骨关节炎的治疗管理的现状，并强调需要填补科学证据与临床实践之间的空白。
