PDF(Pubmed)
Abstract：
Lichen planus (LP) is a chronic, recurrent mucocutaneous inflammatory disease with unclearly defined etiology, where a potential role of several viruses has been considered. This meta-analysis aimed to determine the potential association between HPV and oral LP based on case-control and cross-sectional study results. A systematic search was performed in PubMed, Web of Science (SCI), Google Scholar, and Scopus databases with the last update on 6 March 2024. Pooled data were analyzed by calculating odds ratios (OR) and 95% confidence intervals (CI) with the metafor package for R. A total of 13 studies on 541 cases and 413 controls were included in this meta-analysis. It covered eight countries: India, Iran, Turkey, Czech Republic, Hungary, Italy, Macedonia, and the UK. In seven papers, the differentiation into the erosive-atrophic type and non-erosive-atrophic type of OLP was utilized. HPV infection was associated with at least a two times higher risk for a person with HPV to have OLP, depending on whether original data or filled/trimmed data were used. The OR values were 3.54 [2.01, 6.24] and 2.10 [1.16, 3.82], respectively. This meta-analysis was performed to identify the association between HPV and OLP and revealed that HPV infection was associated with at least a high risk for a person with HPV to develop OLP.
摘要：
扁平苔藓(LP)是一种慢性,复发性皮肤粘膜炎性疾病，病因不明，已经考虑了几种病毒的潜在作用。这项荟萃分析旨在根据病例对照和横断面研究结果确定HPV与口服LP之间的潜在关联。在PubMed中进行了系统的搜索，WebofScience(SCI),谷歌学者，和Scopus数据库，最后一次更新于2024年3月6日。通过计算R的比值比（OR）和95％置信区间（CI）对汇总的数据进行分析。该荟萃分析中包括了541例病例和413例对照的13项研究。它覆盖了八个国家：印度，伊朗,土耳其,捷克共和国,匈牙利,意大利,马其顿,和英国。在七篇论文中，利用OLP的侵蚀性-萎缩性和非侵蚀性-萎缩性。HPV感染与HPV患者患OLP的风险至少高出两倍有关。取决于使用的是原始数据还是填充/修剪的数据。OR值为3.54[2.01,6.24]和2.10[1.16,3.82]，分别。进行这项荟萃分析以确定HPV和OLP之间的关联，并揭示HPV感染至少与HPV患者发展OLP的高风险相关。
