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Abstract：
Background: MOH (medication overuse headache) is regarded as a complication of chronic migraines (CMs), with a general acknowledgment of reciprocal triggering between these two conditions. The present study aims to investigate the clinical parameters of relevance for the development of MOH among patients with CM, as well as for the subtype classification of MOHs. Method: We compared two groups of CM patients, with and without MOH, separated based on their demographic data and migraine characteristics. A subgroup of MOH accompanied by psychiatric co-morbidities (depression, anxiety, sleep disorder) was delineated, and the clinical features of relevance for the progression of MOH into the complicated state were evaluated. Results: The study revealed a higher prevalence of a family history of migraine in both the MOH and potentially complicated MOH subgroups (p < 0.001, p = 0.036), along with a higher prevalence of bilateral pain localization (p = 0.033, 0.021). Symptoms commonly associated with migraines, such as nausea, vomiting, photophobia, phonophobia, and osmophobia, were more common in both the MOH and potentially complicated MOH subgroups (p < 0.05). Furthermore, a positive correlation was found for the frequency (p < 0.001) and severity (p = 0.010) of migraine attacks and the duration of headaches (p = 0.007), atopy (p = 0.017), sleep disturbances (p = 0.011), and emotional stress (p = 0.022) in the MOH group. Conclusion: We found a positive correlation between the prevalence of MOH among patients with CM and a family history of migraines, higher frequency and intensity of headaches, bilateral manifestation, sleep disturbances, and emotional stress. Moreover, symptoms accompanying migraines were found to be more prevalent in individuals with MOH and potentially complicated MOH.
摘要：
背景：MOH（药物过度使用头痛）被认为是慢性偏头痛（CMs）的并发症，普遍承认这两个条件之间的相互触发。本研究旨在探讨与CM患者MOH发展相关的临床参数，以及MOHs的亚型分类。方法:比较两组CM患者,有和没有MOH，根据他们的人口统计数据和偏头痛特征进行分离。MOH的一个亚组伴有精神病合并症(抑郁症，焦虑,睡眠障碍)被描绘，并评估了MOH进展为复杂状态的相关临床特征。结果：研究显示，MOH和潜在复杂MOH亚组中偏头痛家族史的患病率更高（p<0.001，p=0.036）。伴随着双侧疼痛定位的患病率较高（p=0.033，0.021）。通常与偏头痛相关的症状，比如恶心，呕吐,畏光,恐惧症,和恐惧症，在MOH和潜在的复杂性MOH亚组中更常见（p<0.05）。此外，偏头痛发作的频率（p<0.001）和严重程度（p=0.010）和头痛持续时间（p=0.007）呈正相关，特应性（p=0.017），睡眠障碍（p=0.011），MOH组的情绪压力（p=0.022）。结论：我们发现CM患者MOH的患病率与偏头痛家族史呈正相关。头痛的频率和强度更高，双边表现，睡眠障碍,和情绪压力。此外，发现伴随偏头痛的症状在MOH患者和潜在复杂性MOH患者中更为普遍.
