PDF(Pubmed)
Abstract：
Lignans, a class of secondary metabolites found in plants, along with their derivatives, exhibit diverse pharmacological activities, including antioxidant, antimicrobial, anti-inflammatory, and antiangiogenic ones. Angiogenesis, the formation of new blood vessels from pre-existing ones, is a crucial process for cancer growth and development. Several studies have elucidated the synergistic relationship between angiogenesis and inflammation in various inflammatory diseases, highlighting a correlation between inflammation and vascular endothelial growth factor (VEGF)-induced angiogenesis. Thus, the identification of novel molecules capable of modulating VEGF effects presents promising prospects for developing therapies aimed at stabilizing, reversing, or even arresting disease progression. Lignans often suffer from low aqueous solubility and, for their use, encapsulation in a delivery system is needed. In this research, a bioinspired benzoxantene has been encapsulated in solid lipid nanoparticles that have been characterized for their pharmacotechnical properties and their thermotropic behavior. The effects of these encapsulated nanoparticles on angiogenic parameters and inflammation in VEGF-induced angiogenesis were evaluated using human brain microvascular endothelial cells (HBMECs) as a human blood-brain barrier model.
摘要：
木质素,在植物中发现的一类次生代谢产物,连同它们的衍生物，表现出不同的药理活性，包括抗氧化剂，抗菌，抗炎,和抗血管生成的。血管生成,从预先存在的血管形成新的血管，是癌症生长和发展的关键过程。一些研究已经阐明了在各种炎性疾病中血管生成和炎症之间的协同关系。强调炎症和血管内皮生长因子（VEGF）诱导的血管生成之间的相关性。因此，能够调节VEGF效应的新型分子的鉴定为开发旨在稳定的治疗方法提供了有希望的前景。倒车,甚至阻止疾病进展。木脂素通常具有低水溶性，为了他们的使用，需要在递送系统中封装。在这项研究中,一种生物启发的苯并恶胺已被封装在固体脂质纳米颗粒中，该纳米颗粒已被表征为其药理技术特性和热致行为。使用人脑微血管内皮细胞（HBMEC）作为人血脑屏障模型，评估了这些包封的纳米颗粒对VEGF诱导的血管生成参数和炎症的影响。
