PDF(Pubmed)
Abstract：
The whole Hypericum patulum Thunb. plant is utilized in traditional medicine for its properties of clearing heat, detoxifying, soothing meridians, relaxing the liver, and stopping bleeding. In folk medicine, it is frequently used to treat hepatitis, colds, tonsillitis, and bruises. Phytochemical investigation of a 30% ethanol extract of the fresh ripe fruits of H. patulum has resulted in the isolation of two new pinane-type monoterpenoid glycosides 1-2, named patulumside E-F, and three new chain-shaped monoterpenoid glycosides 3-5, named patulumside G-H, J. Their structures were determined using extensive spectroscopic techniques, such as HR-ESI-MS, 1D and 2D NMR spectroscopy, and electronic circular dichroism (ECD) calculation. The anti-inflammatory activities of these compounds were evaluated in the LPS-induced RAW264.7 cells. This research represents the inaugural comprehensive phytochemical study of H. patulum, paving the way for further exploration of monoterpenoid glycosides.
摘要：
整个金丝桃属。植物因其清热特性而被用于传统医学中，解毒,舒缓经络，放松肝脏，止血.在民间医学中，它经常用于治疗肝炎，感冒,扁桃体炎,还有瘀伤.对H.patulum新鲜成熟果实的30％乙醇提取物进行的植物化学研究已分离出两种新的pin烷型单萜苷1-2，称为patulumsideE-F，和三个新的链状单萜苷3-5，命名为patulumsideG-H，J.它们的结构是使用广泛的光谱技术确定的，如HR-ESI-MS，1D和2DNMR光谱，和电子圆二色性（ECD）计算。在LPS诱导的RAW264.7细胞中评价这些化合物的抗炎活性。这项研究代表了对H.patulum的首次全面植物化学研究，为进一步探索单萜苷奠定了基础。
