PDF(Pubmed)
Abstract：
Nucleic acid chemistry is a huge research area that has received new impetus due to the recent explosive success of oligonucleotide therapy. In order for an oligonucleotide to become clinically effective, its monomeric parts are subjected to modifications. Although a large number of redesigned natural nucleic acids have been proposed in recent years, the vast majority of them are combinations of simple modifications proposed over the past 50 years. This review is devoted to the main modifications of the sugar phosphate backbone of natural nucleic acids known to date. Here, we propose a systematization of existing knowledge about modifications of nucleic acid monomers and an acceptable classification from the point of view of chemical logic. The visual representation is intended to inspire researchers to create a new type of modification or an original combination of known modifications that will produce unique oligonucleotides with valuable characteristics.
摘要：
核酸化学是一个巨大的研究领域，由于最近寡核苷酸治疗的爆炸性成功而获得了新的动力。为了使寡核苷酸变得临床有效，其单体部分进行修饰。尽管近年来已经提出了大量重新设计的天然核酸,其中绝大多数是过去50年提出的简单修改的组合。这篇综述致力于迄今为止已知的天然核酸的糖磷酸主链的主要修饰。这里,我们提出了关于核酸单体修饰的现有知识的系统化，并从化学逻辑的角度提出了可接受的分类。视觉表示旨在激励研究人员创建新型修饰或已知修饰的原始组合，这些修饰将产生具有有价值特征的独特寡核苷酸。
